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Journal of Biomedical Optics

Time integrated spectroscopy of turbid media based on the microscopic Beer-Lambert law: application to small-size phantoms having different boundary conditions
Author(s): Hedong Zhang; Tsuneyuki Urakami; Yutaka Tsuchiya; Zukang Lu; Teruo Hiruma
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Paper Abstract

Continued work on time-integrated spectroscopy (TIS) is presented to quantify absorber concentrations in turbid media. We investigated the applicability of the TIS method to small-size media that have different boundary conditions by measuring two 20x20x50mm3 cuboid liquid tissue-like phantoms at various absorption levels (absorption coefficients of the phantom from 25x10-3 to 4.4x10-2 mm?1 at 782 nm and from 3.1x10-3 to 2.7x10-2 mm?1 at 831 nm). The scattering and absorbing solution was filled into ordinary and black-anodized aluminum containers to provide different boundary conditions. By means of a single equation, the absorber concentrations have been recovered within errors of a few percent in both cases. This demonstrates that the TIS method can quantify absorbers in small-size media having different boundary conditions.

Paper Details

Date Published: 1 January 1999
PDF: 8 pages
J. Biomed. Opt. 4(1) doi: 10.1117/1.429905
Published in: Journal of Biomedical Optics Volume 4, Issue 1
Show Author Affiliations
Hedong Zhang, Zhejiang Univ. (China)
Tsuneyuki Urakami, Hamamatsu Photonics K.K. (Japan)
Yutaka Tsuchiya, Hamamatsu Photonics KK (Japan)
Zukang Lu, Zhejiang Univ. (China)
Teruo Hiruma, Hamamatsu Photonics K.K. (Japan)

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