Share Email Print
cover

Journal of Biomedical Optics

Experimental and computational laser tissue welding using a protein patch
Author(s): Ward Small; Nicholas J. Heredia; Duncan J. Maitland; David C. Eder; Peter M. Celliers; Luiz Barroca Da Silva; Richard A. London; Dennis L. Matthews
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

An in vitro study of laser tissue welding mediated with a dye-enhanced protein patch was conducted. Fresh sections of porcine aorta were used for the experiments. Arteriotomies were treated using an indocyanine green dye-enhanced collagen patch activated by an 805-nm continuous-wave fiber-delivered diode laser. Temperature histories of the surface of the weld site were obtained using a hollow glass optical fiber-based two-color infrared thermometer. The experimental effort was complemented by simulations with the LATIS (LAser-TISsue) computer code, which uses coupled Monte Carlo, thermal transport, and mass transport models. Comparison of simulated and experimental thermal data indicated that evaporative cooling clamped the surface temperature of the weld site below 100 °C. For fluences of approximately 200 J/cm2, peak surface temperatures averaged 74°C and acute burst strengths consistently exceeded 0.14x106 dyn/cm (hoop tension). The combination of experimental and simulation results showed that the inclusion of water transport and evaporative losses in the computer code has a significant impact on the thermal distributions and hydration levels throughout the tissue volume. The solid-matrix protein patch provided a means of controllable energy delivery and yielded consistently strong welds.

Paper Details

Date Published: 1 January 1998
PDF: 6 pages
J. Biomed. Opt. 3(1) doi: 10.1117/1.429866
Published in: Journal of Biomedical Optics Volume 3, Issue 1
Show Author Affiliations
Ward Small, Lawrence Livermore National Lab. (United States)
Nicholas J. Heredia, Lawrence Livermore National Lab. (United States)
Duncan J. Maitland, Lawrence Livermore National Lab. (United States)
David C. Eder, Lawrence Livermore National Lab. (United States)
Peter M. Celliers, Lawrence Livermore National Lab. (United States)
Luiz Barroca Da Silva, Lawrence Livermore National Lab. (United States)
Richard A. London, Lawrence Livermore National Lab. (United States)
Dennis L. Matthews, Lawrence Livermore National Lab. (United States)


© SPIE. Terms of Use
Back to Top