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Journal of Biomedical Optics

Computer-assisted intra-operative magnetic resonance imaging monitoring of interstitial laser therapy in the brain: a case report
Author(s): Nobuhiko Hata; Paul R. Morrison; Joachim Kettenbach; Peter McLaren Black; Ron Kikinis; Ferenc A. Jolesz
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Paper Abstract

Hardware and software for a customized system to use magnetic resonance imaging (MRI) to noninvasively monitor laser-induced interstitial thermal therapy of brain tumors are reported. An open-configuration interventional MRI unit was used to guide optical fiber placement and monitor the deposition of laser energy into the targeted lesion. T1-weighted fast spin echo and gradient echo images were used to monitor the laser tissue interaction. The images were transferred from the MRI scanner to a customized research workstation and were processed intraoperatively. Newly developed software enabled rapid (27–221 ms) availability of calculated images. A case report is given showing images which reveal the laser–tissue interaction. The system design is feasible for on-line monitoring of interstitial laser therapy.

Paper Details

Date Published: 1 July 1998
PDF: 8 pages
J. Biomed. Opt. 3(3) doi: 10.1117/1.429857
Published in: Journal of Biomedical Optics Volume 3, Issue 3
Show Author Affiliations
Nobuhiko Hata, Brigham & Women's Hospital (Japan)
Paul R. Morrison, Harvard Medical School (United States)
Joachim Kettenbach, Brigham & Womens Hospital (United States)
Peter McLaren Black, Brigham & Women's Hospital (United States)
Ron Kikinis, Brigham & Womens Hospital (United States)
Ferenc A. Jolesz, Brigham & Womens Hospital (United States)


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