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Journal of Biomedical Optics

Biocompatibility of Laser-deposited Hydroxyapatite Coatings on Titanium and Polymer Implant Materials
Author(s): Evgueni N. Antonov; Victor N. Bagratashvili; Vladimir K. Popov; Emil N. Sobol; Steven Howdle; Christine Joiner; Kate G. Parker; Terry L. Parker; Alexander A. Doktorov; Valeri B. Likhanov; Alexander I. Volozhin; Sergey Sergeivich Alimpiev; Sergey M. Nikiforov
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Paper Abstract

We have investigated the biocompatibility of calcium phosphate coatings deposited by pulsed laser ablation from hydroxyapatite (HA) targets onto polyethylene and Teflon substrates. It was found that the cell density, attachment, and morphology of primary rat calvaria osteoblasts were influenced by both the original polymer and by the nature of the apatite coatings. HA coatings on Teflon were found to have higher biocompatibility in terms of cell adhesion and spreading. In vivo studies of bone response to coatings deposited by KrF excimer and CO2 lasers on commercial Ti6A14V alloy implants show that both deposition techniques suppress fibrous tissue formation and promote osteogenesis.

Paper Details

Date Published: 1 October 1998
PDF: 6 pages
J. Biomed. Opt. 3(4) doi: 10.1117/1.429852
Published in: Journal of Biomedical Optics Volume 3, Issue 4
Show Author Affiliations
Evgueni N. Antonov, Research Ctr. for Technological Lasers (Russia)
Victor N. Bagratashvili, Research Ctr. for Technological Lasers (Russia)
Vladimir K. Popov, Research Ctr. for Technological Lasers (Russia)
Emil N. Sobol, Research Ctr. for Technologica Tech Lasers (Russia)
Steven Howdle, Univ. of Nottingham (United Kingdom)
Christine Joiner, Univ. of Nottingham (United Kingdom)
Kate G. Parker, Univ. of Nottingham (United Kingdom)
Terry L. Parker, Univ. of Nottingham (United Kingdom)
Alexander A. Doktorov, Russian Academy of Science (Russia)
Valeri B. Likhanov, Russian Academy of Science (Russia)
Alexander I. Volozhin, Russian Academy of Science (Russia)
Sergey Sergeivich Alimpiev, Instittute of General Physics (Russia)
Sergey M. Nikiforov, Institute of General Physics (Russia)


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