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Journal of Biomedical Optics • Open Access

Simultaneous fluorescence and positron emission tomography for in vivo imaging of small animals
Author(s): Bin Zhang; Fei Liu; Yanyan Xu; Jing Bai; Shuangquan Liu; Baoci Shan; Xiaochun Zhang; Jianwen Luo

Paper Abstract

Simultaneous positron emission tomography (PET) and fluorescence tomography (FT) for in vivo imaging of small animals is proposed by a dual-modality system. This system combines a charge-coupled device-based near-infrared fluorescence imaging with a planar detector pair-based PET. With [18F]-2-fluoro-2-deoxy-d-glucose radioactive tracer and the protease activated fluorescence probe, on the one hand, the simultaneous metabolic activity and protease activity in tumor region are revealed by the PET and FT, respectively. On the other hand, the protease activity both on the surface layer and the deep tissue of the tumor is provided by the fluorescence reflection imaging and FT, respectively.

Paper Details

Date Published: 1 December 2011
PDF: 4 pages
J. Biomed. Opt. 16(12) 120511 doi: 10.1117/1.3665438
Published in: Journal of Biomedical Optics Volume 16, Issue 12
Show Author Affiliations
Bin Zhang, Tsinghua Univ. (China)
Fei Liu, Tsinghua Univ. (China)
Yanyan Xu, Tsinghua Univ. (China)
Jing Bai, Tsinghua Univ. (China)
Shuangquan Liu, Institute of High Energy Physics (China)
Baoci Shan, Institute of High Energy Physics (China)
Xiaochun Zhang, XinAoMDT Technology Co., Ltd. (China)
Jianwen Luo, Tsinghua Univ. (China)

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