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Journal of Biomedical Optics

Optical imaging of alpha emitters: simulations, phantom, and in vivo results
Author(s): Federico Boschi; Andrea Sbarbati; Sergio Lo Meo; Pier Luca Rossi; Riccardo Calandrino; Antonello E. Spinelli
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Paper Abstract

There has been growing interest in investigating both the in vitro and in vivo detection of optical photons from a plethora of beta emitters using optical techniques. In this paper we have investigated an alpha particle induced fluorescence signal by using a commercial CCD-based small animal optical imaging system. The light emission of a 241Am source was simulated using GEANT4 and tested in different experimental conditions including the imaging of in vivo tissue. We believe that the results presented in this work can be useful to describe a possible mechanism for the in vivo detection of alpha emitters used for therapeutic purposes.

Paper Details

Date Published: 1 December 2011
PDF: 6 pages
J. Biomed. Opt. 16(12) 126011 doi: 10.1117/1.3663441
Published in: Journal of Biomedical Optics Volume 16, Issue 12
Show Author Affiliations
Federico Boschi, Univ. degli Studi di Verona (Italy)
Andrea Sbarbati, Univ. degli Studi di Verona (Italy)
Sergio Lo Meo, National Institute for Insurance against Accidents at Work (Italy)
Pier Luca Rossi, Univ. degli Studi di Bologna (Italy)
Riccardo Calandrino, Fondazione San Raffaele del Monte Tabor (Italy)
Antonello E. Spinelli, Fondazione San Raffaele del Monte Tabor (Italy)

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