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Journal of Biomedical Optics • Open Access

Effects of motion on optical properties in the spatial frequency domain
Author(s): John Quan M. Nguyen; Rolf B. Saager; Anthony J. Durkin; David J. Cuccia; Kristen M. Kelly; James Jakowatz; David J. Hsiang

Paper Abstract

Spatial frequency domain imaging (SFDI) is a noncontact and wide-field optical imaging technology currently being used to study the optical properties and chromophore concentrations of in vivo skin including skin lesions of various types. Part of the challenge of developing a clinically deployable SFDI system is related to the development of effective motion compensation strategies, which in turn, is critical for recording high fidelity optical properties. Here we present a two-part strategy for SFDI motion correction. After verifying the effectiveness of the motion correction algorithm on tissue-simulating phantoms, a set of skin-imaging data was collected in order to test the performance of the correction technique under real clinical conditions. Optical properties were obtained with and without the use of the motion correction technique. The results indicate that the algorithm presented here can be used to render optical properties in moving skin surfaces with fidelities within 1.5% of an ideal stationary case and with up to 92.63% less variance. Systematic characterization of the impact of motion variables on clinical SFDI measurements reveals that until SFDI instrumentation is developed to the point of instantaneous imaging, motion compensation is necessary for the accurate localization and quantification of heterogeneities in a clinical setting.

Paper Details

Date Published: 1 December 2011
PDF: 10 pages
J. Biomed. Opt. 16(12) 126009 doi: 10.1117/1.3662454
Published in: Journal of Biomedical Optics Volume 16, Issue 12
Show Author Affiliations
John Quan M. Nguyen, Beckman Laser Institute and Medical Clinic (United States)
Rolf B. Saager, Beckman Laser Institute and Medical Clinic (United States)
Anthony J. Durkin, Beckman Laser Institute and Medical Clinic (United States)
David J. Cuccia, Modulated Imaging, Inc. (United States)
Kristen M. Kelly, Univ. of California, Irvine School of Medicine (United States)
James Jakowatz, Univ. of California, Irvine (United States)
David J. Hsiang, Univ. of California, Irvine (United States)

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