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Journal of Biomedical Optics • Open Access

Correlation of within-individual fluctuation of depressed mood with prefrontal cortex activity during verbal working memory task: optical topography study
Author(s): Hiroki Sato; Takusige Katura; Hideaki Koizumi; Ryuta Aoki; Ryoichi Matsuda

Paper Abstract

Previous studies showed that interindividual variations in mood state are associated with prefrontal cortex (PFC) activity. In this study, we focused on the depressed-mood state under natural circumstances and examined the relationship between within-individual changes over time in this mood state and PFC activity. We used optical topography (OT), a functional imaging technique based on near-infrared spectroscopy, to measure PFC activity for each participant in three experimental sessions repeated at 2-week intervals. In each session, the participants completed a self-report questionnaire of mood state and underwent OT measurement while performing verbal and spatial working memory (WM) tasks. The results showed that changes in the depressed-mood score between successive sessions were negatively correlated with those in the left PFC activation for the verbal WM task (ρ = −0.56, p < 0.05). In contrast, the PFC activation for the spatial WM task did not co-vary with participants' mood changes. We thus demonstrated that PFC activity during a verbal WM task varies depending on the participant's depressed mood state, independent of trait factors. This suggests that using optical topography to measure PFC activity during a verbal WM task can be used as a potential state marker for an individual's depressed mood state.

Paper Details

Date Published: 1 December 2011
PDF: 8 pages
J. Biomed. Opt. 16(12) 126007 doi: 10.1117/1.3662448
Published in: Journal of Biomedical Optics Volume 16, Issue 12
Show Author Affiliations
Hiroki Sato, Hitachi, Ltd. (Japan)
Takusige Katura, Hitachi, Ltd. (Japan)
Hideaki Koizumi, Hitachi, Ltd. (Japan)
Ryuta Aoki, The Univ. of Tokyo (Japan)
Ryoichi Matsuda, The Univ. of Tokyo (Japan)


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