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Journal of Biomedical Optics • Open Access

Effects of erythrocyte oxygenation on optoacoustic signals

Paper Abstract

A theoretical model examining the effects of erythrocyte oxygenation on optoacoustic (OA) signals is presented. Each erythrocyte is considered as a fluid sphere and its optical absorption is defined by its oxygen saturation state. The OA field generated by a cell is computed by solving the wave equation in the frequency domain with appropriate boundary conditions. The resultant field from many cells is simulated by summing the pressure waves emitted by individual cells. A Monte Carlo algorithm generates 2-D spatially random distributions of oxygenated and deoxygenated erythrocytes. Oxygen saturation levels of oxygenated cells a assumed to be 100% and 0% for deoxygenated cells. The OA signal amplitude decreases monotonically for the 700-nm laser source and increases monotonically for 1000 nm optical radiation when blood oxygen saturation varies from 0 to 100%. An approximately sixfold decrease and fivefold increase of the OA signal amplitude were computed at those wavelengths, respectively. The OA spectral power in the low-frequency range (<10 MHz) and in the very high-frequency range (<100 MHz) decreases for 700 nm and increases for 1000 nm with increasing blood oxygen saturation. This model provides a theoretical framework to study the erythrocyte oxygenation-dependent OA signals.

Paper Details

Date Published: 1 November 2011
PDF: 10 pages
J. Biomed. Opt. 16(11) 115003 doi: 10.1117/1.3655355
Published in: Journal of Biomedical Optics Volume 16, Issue 11
Show Author Affiliations
Ratan K. Saha, Ryerson Univ. (Canada)
Michael C. Kolios, Ryerson Univ. (Canada)


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