Share Email Print
cover

Journal of Biomedical Optics • Open Access

Measurement of oxygen saturation in small retinal vessels with adaptive optics confocal scanning laser ophthalmoscope
Author(s): Hao Li; Jing Lu; Guohua Shi; Yudong Zhang

Paper Abstract

We have used an adaptive optics confocal scanning laser ophthalmoscope to assess oxygen saturation in small retinal vessels. Images of the vessels with a diameter smaller than 50 μm are recorded at oxygen sensitive and isosbestic wavelengths (680 and 796 nm, respectively). The vessel optical densities (ODs) are determined by a computer algorithm. Then, OD ratios (ODRs), which are inversely proportional to oxygen saturation, are calculated. The results show that arterial ODRs are significantly smaller than venous ODRs, indicating that oxygen saturation in the artery is higher than that in the vein. To the best of our knowledge, this is the first noninvasive measurement of oxygen saturation in small retinal vessels.

Paper Details

Date Published: 1 November 2011
PDF: 4 pages
J. Biomed. Opt. 16(11) 110504 doi: 10.1117/1.3655354
Published in: Journal of Biomedical Optics Volume 16, Issue 11
Show Author Affiliations
Hao Li, Institute of Optics and Electronics (China)
Jing Lu, Institute of Optics and Electronics (China)
Guohua Shi, Institute of Optics and Electronics (China)
Yudong Zhang, Institute of Optics and Electronics (China)


© SPIE. Terms of Use
Back to Top