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Journal of Biomedical Optics • Open Access

Reduction of image artifacts in three-dimensional optical coherence tomography of skin in vivo
Author(s): Yih Miin Liew; Robert A. McLaughlin; David D. Sampson; Fiona M. Wood

Paper Abstract

This paper presents results of in vivo studies on the effect of refractive index-matching media on image artifacts in optical coherence tomography (OCT) images of human skin. These artifacts present as streaks of artificially low backscatter and displacement or distortion of features. They are primarily caused by refraction and scattering of the OCT light beam at the skin surface. The impact of the application of glycerol and ultrasound gel is assessed on both novel skin-mimicking phantoms and in vivo human skin, including assessment of the epidermal thickening caused by the media. Based on our findings, recommendations are given for optimal OCT imaging of skin in vivo.

Paper Details

Date Published: 1 November 2011
PDF: 11 pages
J. Biomed. Opt. 16(11) 116018 doi: 10.1117/1.3652710
Published in: Journal of Biomedical Optics Volume 16, Issue 11
Show Author Affiliations
Yih Miin Liew, The Univ. of Western Australia (Australia)
Robert A. McLaughlin, The Univ. of Western Australia (Australia)
David D. Sampson, The Univ. of Western Australia (Australia)
Fiona M. Wood, The Univ. of Western Australia (Australia)

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