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Journal of Biomedical Optics

Optical spectroscopy combined with high-resolution magnetic resonance imaging for digestive wall assessment: endoluminal bimodal probe conception and characterization in vitro, on organic sample and in vivo on a rabbit
Author(s): Anoop Ramgolam; Raphaël Sablong; Olivier Beuf; Lionel Lafarge; Hervé Saint-Jalmes
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Paper Abstract

Colorectal cancer is a major health issue worldwide. Conventional white light endoscopy (WLE) coupled to histology is considered as the gold standard today and is the most widespread technique used for colorectal cancer diagnosis. However, during the early stages, colorectal cancer is very often characterized by flat adenomas which develop just underneath the mucosal surface. The use of WLE, which is heavily based on the detection of morphological changes, becomes quite delicate due to subtle or quasi-invisible morphological changes of the colonic lining. Several techniques are currently being investigated in the scope of providing new tools that would allow such a diagnostic or assist actual techniques in so doing. We hereby present a novel technique where high spatial resolution MRI is combined with autofluorescence and reflectance spectroscopy in a bimodal endoluminal probe to extract morphological data and biochemical information, respectively. The design and conception of the endoluminal probe are detailed and the promising preliminary results obtained in vitro (home-built phantom containing eosin and rhodamine B), on an organic sample (the kiwi fruit) and in vivo on a rabbit are presented and discussed.

Paper Details

Date Published: 1 November 2011
PDF: 14 pages
J. Biomed. Opt. 16(11) 117005 doi: 10.1117/1.3646917
Published in: Journal of Biomedical Optics Volume 16, Issue 11
Show Author Affiliations
Anoop Ramgolam, CREATIS-LRMN INSA (France)
Raphaël Sablong, CREATIS-LRMN INSA (France)
Olivier Beuf, CREATIS-LRMN INSA (France)
Lionel Lafarge, Institut National des Sciences Appliquées de Lyon (France)
Hervé Saint-Jalmes, Univ. de Rennes 1 (France)

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