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Journal of Biomedical Optics • Open Access

Toward soft-tissue elastography using digital holography to monitor surface acoustic waves
Author(s): Shiguang Li; Karan D. Mohan; William W. Sanders; Amy L. Oldenburg

Paper Abstract

Measuring the elasticity distribution inside the human body is of great interest because elastic abnormalities can serve as indicators of several diseases. We present a method for mapping elasticity inside soft tissues by imaging surface acoustic waves (SAWs) with digital holographic interferometry. With this method, we show that SAWs are consistent with Rayleigh waves, with velocities proportional to the square root of the elastic modulus greater than 2-40 kPa in homogeneous tissue phantoms. In two-layer phantoms, the SAW velocity transitions approximately from that of the lower layer to that of the upper layer as frequency is increased in agreement with the theoretical relationship between SAW dispersion and the depth-dependent stiffness profile. We also observed deformation in the propagation direction of SAWs above a stiff inclusion placed 8 mm below the surface. These findings demonstrate the potential for quantitative digital holography-based elastography of soft tissues as a noninvasive method for disease detection.

Paper Details

Date Published: 1 November 2011
PDF: 8 pages
J. Biomed. Opt. 16(11) 116005 doi: 10.1117/1.3646211
Published in: Journal of Biomedical Optics Volume 16, Issue 11
Show Author Affiliations
Shiguang Li, The Univ. of North Carolina at Chapel Hill (United States)
Karan D. Mohan, The Univ. of North Carolina at Chapel Hill (United States)
William W. Sanders, The Univ. of North Carolina at Chapel Hill (United States)
Amy L. Oldenburg, The Univ. of North Carolina at Chapel Hill (United States)


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