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Journal of Biomedical Optics • Open Access

Functional photoacoustic microscopy of pH

Paper Abstract

pH is a tightly regulated indicator of metabolic activity. In mammalian systems, an imbalance of pH regulation may result from or result in serious illness. In this paper, we report photoacoustic microscopy (PAM) of a commercially available pH-sensitive fluorescent dye (SNARF-5F carboxylic acid) in tissue phantoms. We demonstrated that PAM is capable of pH imaging in absolute values at tissue depths of up to 2.0 mm, greater than possible with other forms of optical microscopy.

Paper Details

Date Published: 1 October 2011
PDF: 4 pages
J. Biomed. Opt. 16(10) 100503 doi: 10.1117/1.3644495
Published in: Journal of Biomedical Optics Volume 16, Issue 10
Show Author Affiliations
Mohammad R. Chatni, Washington Univ. in St. Louis (United States)
Junjie Yao, Washington Univ. in St. Louis (United States)
Amos Danielli, Washington Univ. in St. Louis (United States)
Christopher P. Favazza, Washington Univ. in St. Louis (United States)
Konstantin I. Maslov, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


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