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Journal of Biomedical Optics • Open Access

Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography
Author(s): Yuting Lin; David A. Thayer; Orhan Nalcioglu; Gultekin Gulsen

Paper Abstract

We present a magnetic resonance (MR)-guided near-infrared dynamic contrast enhanced diffuse optical tomography (DCE-DOT) system for characterization of tumors using an optical contrast agent (ICG) and a MR contrast agent [Gd-diethylenetriaminepentaacetic acid (DTPA)] in a rat model. Both ICG and Gd-DTPA are injected and monitored simultaneously using a combined MRI-DOT system, resulting in accurate co-registration between two imaging modalities. Fisher rats bearing R3230 breast tumor are imaged using this hybrid system. For the first time, enhancement kinetics of the exogenous contrast ICG is recovered from the DCE-DOT data using MR anatomical a priori information. As tumors grow, they undergo necrosis and the tissue transforms from viable to necrotic. The results show that the physiological changes between viable and necrotic tissue can be differentiated more accurately based on the ICG enhancement kinetics when MR anatomical information is utilized.

Paper Details

Date Published: 1 October 2011
PDF: 5 pages
J. Biomed. Opt. 16(10) 106015 doi: 10.1117/1.3643342
Published in: Journal of Biomedical Optics Volume 16, Issue 10
Show Author Affiliations
Yuting Lin, Univ. of California, Irvine (United States)
David A. Thayer, Univ. of California, Irvine (United States)
Orhan Nalcioglu, Univ. of California, Irvine (United States)
Gultekin Gulsen, Univ. of California, Irvine (United States)


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