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Journal of Biomedical Optics • Open Access

Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography
Author(s): Claire Robertson; Zhongping Chen; Steven C. George; Sang-Won Lee; Yeh-Chan Ahn; Sari Mahon; Matthew Brenner

Paper Abstract

Optical coherence tomography (OCT) is a nondestructive imaging technique offering high temporal and spatial resolution, which makes it a natural choice for assessing tissue mechanical properties. We have developed methods to mechanically analyze the compliance of the rabbit trachea in vivo using tissue deformations induced by tidal breathing, offering a unique tool to assess the behavior of the airways during their normal function. Four-hundred images were acquired during tidal breathing with a custom-built endoscopic OCT system. The surface of the tissue was extracted from a set of these images via image processing algorithms, filtered with a bandpass filter set at respiration frequency to remove cardiac and probe motion, and compared to ventilatory pressure to calculate wall compliance. These algorithms were tested on elastic phantoms to establish reliability and reproducibility. The mean tracheal wall compliance (in five animals) was 1.3±0.3×10−5 (mm Pa)−1. Unlike previous work evaluating airway mechanics, this new method is applicable in vivo, noncontact, and loads the trachea in a physiological manner. The technique may have applications in assessing airway mechanics in diseases such as asthma that are characterized by significant airway remodeling.

Paper Details

Date Published: 1 October 2011
PDF: 9 pages
J. Biomed. Opt. 16(10) 106011 doi: 10.1117/1.3642006
Published in: Journal of Biomedical Optics Volume 16, Issue 10
Show Author Affiliations
Claire Robertson, Univ. of California, Irvine (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)
Steven C. George, Univ. of California, Irvine (United States)
Sang-Won Lee, Electronics and Telecommunications Research Institute (Korea, Republic of)
Yeh-Chan Ahn, Pukyong National Univ. (Korea, Republic of)
Sari Mahon, Beckman Laser Institute and Medical Clinic (United States)
Matthew Brenner, Univ. of California, Irvine (United States)

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