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Journal of Biomedical Optics

Isolating the sources of widespread physiological fluctuations in functional near-infrared spectroscopy signals
Author(s): Yunjie Tong; Lia Maria Hocke; Blaise B. Frederick
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Paper Abstract

Physiological fluctuations at low frequency (<0.1 Hz) are prominent in functional near-infrared spectroscopy (fNIRS) measurements in both resting state and functional task studies. In this study, we used the high spatial resolution and full brain coverage of functional magnetic resonance imaging (fMRI) to understand the origins and commonalities of these fluctuations. Specifically, we applied a newly developed method, regressor interpolation at progressive time delays, to analyze concurrently recorded fNIRS and fMRI data acquired both in a resting state study and in a finger tapping study. The method calculates the voxelwise correlations between blood oxygen level dependent (BOLD) fMRI and fNIRS signals with different time shifts and localizes the areas in the brain that highly correlate with the fNIRS signal recorded at the surface of the head. The results show the wide spatial distribution of this physiological fluctuation in BOLD data, both in task and resting states. The brain areas that are highly correlated with global physiological fluctuations observed by fNIRS have a pattern that resembles the venous system of the brain, indicating the blood fluctuation from veins on the brain surface might strongly contribute to the overall fNIRS signal.

Paper Details

Date Published: 1 October 2011
PDF: 12 pages
J. Biomed. Opt. 16(10) 106005 doi: 10.1117/1.3638128
Published in: Journal of Biomedical Optics Volume 16, Issue 10
Show Author Affiliations
Yunjie Tong, McLean Hospital (United States)
Lia Maria Hocke, McLean Hospital (United States)
Blaise B. Frederick, McLean Hospital (United States)

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