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Journal of Biomedical Optics

Optical coherent tomography: promising in vivo measurement of hair shaft cross section
Author(s): Natalie Garcia Bartels; Karola Stieler; Ulrike Blume-Peytavi; Heike Richter; Alexa Patzelt; Jürgen M. Lademann
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Paper Abstract

Variations in hair shaft morphology reflect ethnical diversity, but may also indicate internal diseases, nutritional deficiency, or hair and scalp disorders. The measurement and the follow-up of the hair shaft thickness over a defined period of time would be a valuable diagnostic tool in clinical practice. Standard light microscopy (LM) measurements require the epilation of hair shafts and frequently yield inaccurate values caused by the elliptic geometry of human hair shafts. Optical coherence tomography (OCT) is a noninvasive investigation method based on the principles of Michelson interferometry with a detection depth of approximately 1 mm in human skin. Two-dimensional images of the cross sections of tissue samples at a resolution of approximately 10 μm are produced, which allows convenient calculation of hair shaft thickness. To evaluate this new methodology for hair shaft thickness measurements, hair shafts taken from 28 healthy volunteers were analyzed by in vivo OCT and compared to standard in vitro LM measurements of hair shaft thickness. OCT yielded highly reproducible measurements of hair shaft thickness with a distinctly reduced variation compared to standard LM. This technique offers a unique opportunity for in vivo measurement and a follow-up of the kinetics of hair shaft thickness in humans during medical therapy.

Paper Details

Date Published: 1 September 2011
PDF: 6 pages
J. Biomed. Opt. 16(9) 096003 doi: 10.1117/1.3626210
Published in: Journal of Biomedical Optics Volume 16, Issue 9
Show Author Affiliations
Natalie Garcia Bartels, Charité Universitätsmedizin Berlin (Germany)
Karola Stieler, Charité Universitätsmedizin Berlin (Germany)
Ulrike Blume-Peytavi, Charité Universitätsmedizin Berlin (Germany)
Heike Richter, Charité Universitätsmedizin Berlin (Germany)
Alexa Patzelt, Charité Universitätsmedizin Berlin (Germany)
Jürgen M. Lademann, Charité Universitätsmedizin Berlin (Germany)


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