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Journal of Biomedical Optics • Open Access

Three-dimensional photoacoustic tomography based on the focal-line concept

Paper Abstract

A full ring ultrasonic array-based photoacoustic tomography system was recently developed for small animal brain imaging. The 512-element array is cylindrically focused in the elevational direction, and can acquire a two-dimensional (2D) image in 1.6 s. In this letter, we demonstrate the three-dimensional (3D) imaging capability of this system. A novel 3D reconstruction algorithm was developed based on the focal-line concept. Compared to 3D images acquired simply by stacking a series of 2D images, the 3D focal-line reconstruction method renders images with much less artifacts, and improves the elevational resolution by 30% and the signal-to-noise ratio by two times. The effectiveness of the proposed algorithm was first validated by numerical simulations and then demonstrated with a hair phantom experiment and an ex vivo mouse embryo experiment.

Paper Details

Date Published: 1 September 2011
PDF: 4 pages
J. Biomed. Opt. 16(9) 090505 doi: 10.1117/1.3625576
Published in: Journal of Biomedical Optics Volume 16, Issue 9
Show Author Affiliations
Jun Xia, Washington Univ. in St. Louis (United States)
Zijian Guo, Washington Univ. in St. Louis (United States)
Konstantin I. Maslov, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)
Andres Aguirre, Univ. of Connecticut (United States)
Quing Zhu, Univ. of Connecticut (United States)
Christopher Percival, The Pennsylvania State Univ. (United States)

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