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Journal of Biomedical Optics • Open Access

Optical microangiography provides an ability to monitor responses of cerebral microcirculation to hypoxia and hyperoxia in mice

Paper Abstract

In vivo imaging of microcirculation can improve our fundamental understanding of cerebral microhemodynamics under various physiological challenges, such as hypoxia and hyperoxia. However, existing techniques often involve the use of invasive procedures or exogenous contrast agents, which would inevitably perturb the intrinsic physiologic responses of microcirculation being investigated. We report ultrahigh sensitive optical microangiography (OMAG) for label-free monitoring of microcirculation responses challenged by oxygen inhalation. For the first time, we demonstrate that OMAG is capable of showing the impact of acute hypoxia and hyperoxia on microhemodynamic activities, including the passive and active modulation of microvascular density and flux regulation, within capillary and noncapillary vessels in rodents in vivo. The ability of OMAG to functionally image the intact microcirculation promises future applications for studying cerebral diseases.

Paper Details

Date Published: 1 September 2011
PDF: 5 pages
J. Biomed. Opt. 16(9) 096019 doi: 10.1117/1.3625238
Published in: Journal of Biomedical Optics Volume 16, Issue 9
Show Author Affiliations
Yali Jia, Univ. of Washington (United States)
Peng Li, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)

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