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Journal of Biomedical Optics • Open Access

Laser speckle contrast imaging of cerebral blood flow in freely moving animals
Author(s): Peng Miao; Shanbao Tong; Hongyang Lu; Qi Liu; Yao Li

Paper Abstract

We designed a miniature laser speckle imager that weighs ∼20 g and is 3.1-cm high for full-field high-resolution imaging of cerebral blood flow (CBF) in freely moving animals. Coherent laser light illuminates the cortex through a multimode optical fiber bundle fixed onto the supporting frame of the imager. The reflected lights are then collected by a miniature macrolens system and imaged by a high-resolution CMOS camera at a high frame rate (50 fps). Using this miniature imager, we achieve high spatiotemporal resolution laser speckle contrast imaging of CBF in freely moving animals in real time.

Paper Details

Date Published: 1 September 2011
PDF: 4 pages
J. Biomed. Opt. 16(9) 090502 doi: 10.1117/1.3625231
Published in: Journal of Biomedical Optics Volume 16, Issue 9
Show Author Affiliations
Peng Miao, Shanghai Jiao Tong Univ. (China)
Shanbao Tong, Shanghai Jiao Tong Univ. (China)
Hongyang Lu, Shanghai Jiao Tong Univ. (China)
Qi Liu, Shanghai Jiao Tong Univ. (China)
Yao Li, Shanghai Jiao Tong Univ. (China)


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