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Journal of Biomedical Optics

Infrared spectroscopic imaging of renal tumor tissue
Author(s): Valdas Sablinskas; Vidita Urboniene; Justinas Ceponkus; Arvydas Laurinavicius; Darius Dasevicius; Feliksas Jankevicius; Vaiva Hendrixson; Edmund Koch; Gerald Steiner
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Paper Abstract

Fourier transform infrared (FTIR) spectroscopic imaging has been used to probe the biochemical composition of human renal tumor tissue and adjacent normal tissue. Freshly resected renal tumor tissue from surgery was prepared as a thin cryosection and examined by FTIR spectroscopic imaging. Tissue types could be discriminated by utilizing a combination of fuzzy k-means cluster analysis and a supervised classification algorithm based on a linear discriminant analysis. The spectral classification is compared and contrasted with the histological stained image. It is further shown that renal tumor cells have spread in adjacent normal tissue. This study demonstrates that FTIR spectroscopic imaging can potentially serve as a fast and objective approach for discrimination of renal tumor tissue from normal tissue and even in the detection of tumor infiltration in adjacent tissue.

Paper Details

Date Published: 1 September 2011
PDF: 8 pages
J. Biomed. Opt. 16(9) 096006 doi: 10.1117/1.3622292
Published in: Journal of Biomedical Optics Volume 16, Issue 9
Show Author Affiliations
Valdas Sablinskas, Vilnius Univ. (Lithuania)
Vidita Urboniene, Vilnius Univ. (Lithuania)
Justinas Ceponkus, Vilnius Univ. (Lithuania)
Arvydas Laurinavicius, Vilnius Univ. (Lithuania)
Darius Dasevicius, Vilnius Univ. (Lithuania)
Feliksas Jankevicius, Vilnius Univ. (Lithuania)
Vaiva Hendrixson, Vilnius Univ. (Lithuania)
Edmund Koch, Technische Univ. Dresden (Germany)
Gerald Steiner, Technische Univ. Dresden (Germany)

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