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Journal of Biomedical Optics

Correlation of functional and resting state connectivity of cerebral oxy-, deoxy-, and total hemoglobin concentration changes measured by near-infrared spectrophotometry
Author(s): Ursula Wolf; Vladislav Toronov; Jee Hyun Choi; Rajarsi Gupta; Antonios Michalos; Enrico Gratton; Martin Wolf
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Paper Abstract

The aim is to study cerebral vascular functional connectivity during motor tasks and resting state using multichannel frequency-domain near-infrared spectrophotometry. Maps of 5.7 × 10.8 cm size displaying changes in cerebral oxyhemoglobin (O2Hb), deoxyhemoglobin (HHb), and total hemoglobin (tHb) concentrations were measured in the motor cortex in 12 subjects (mean age of 28.8±12.7 yrs) during resting state and during two palm squeezing tasks with different timing. For each condition, phase plane plots, cross correlation functions, and connectivity indices were generated for O2Hb, HHb, and tHb. The amplitude of the concentration changes in O2Hb and HHb depends on the age of the subject. We found large regions of connectivity, which were similar for resting state and task conditions. This means the spatial relationships during resting state, when changes in O2Hb, HHb, and tHb corresponded to spontaneous oscillations, were correlated to the spatial patterns during the activation tasks, when changes in O2Hb, HHb, and tHb concentration were related to the alternation of stimulation and rest. Thus, the vascular functional connectivity was also present during resting state. The findings suggest that the vascular response to functional activation may be a nonlinear synchronization phenomenon and that resting state processes are more important than previously expected.

Paper Details

Date Published: 1 August 2011
PDF: 13 pages
J. Biomed. Opt. 16(8) 087013 doi: 10.1117/1.3615249
Published in: Journal of Biomedical Optics Volume 16, Issue 8
Show Author Affiliations
Ursula Wolf, Univ. of California, Irvine (United States)
Vladislav Toronov, Ryerson Univ. (Canada)
Jee Hyun Choi, Korea Institute of Science and Technology (Korea, Republic of)
Rajarsi Gupta, Univ. of Illinois at Urbana-Champaign (United States)
Antonios Michalos, Univ. of Illinois at Urbana-Champaign (United States)
Enrico Gratton, Univ. of California, Irvine (United States)
Martin Wolf, Univ. Hospital Zürich (Switzerland)

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