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Journal of Biomedical Optics • Open Access

Enhanced laser tissue soldering using indocyanine green chromophore and gold nanoshells combination
Author(s): Mohammad E. Khosroshahi; Mohammad S. Nourbakhsh

Paper Abstract

Gold nanoshells (GNs) are new materials that have an optical response dictated by the plasmon resonance. The wavelength at which the resonance occurs depends on the core and shell sizes. The purposes of this study were to use the combination of indocyanine green (ICG) and different concentration of gold nanoshells for skin tissue soldering and also to examine the effect of laser soldering parameters on the properties of repaired skin. Two mixtures of albumin solder and different combinations of ICG and gold nanoshells were prepared. A full thickness incision of 2 × 20 mm2 was made on the surface and after addition of mixtures it was irradiated by an 810 nm diode laser at different power densities. The changes of tensile strength (σt) due to temperature rise, number of scan (Ns), and scan velocity (Vs) were investigated. The results showed at constant laser power density (I), σt of repaired incisions increases by increasing the concentration of gold nanoshells in solder, Ns, and decreasing Vs. It was demonstrated that laser soldering using combination of ICG + GNs could be practical provided the optothermal properties of the tissue are carefully optimized. Also, the tensile strength of soldered skin is higher than skins that soldered with only ICG or GNs. In our case, this corresponds to σt = 1800 g cm-2 at I ∼ 47 Wcm−2, T ∼ 85 ºC, Ns = 10, and Vs = 0.3 mms−1.

Paper Details

Date Published: 1 August 2011
PDF: 8 pages
J. Biomed. Opt. 16(8) 088002 doi: 10.1117/1.3611001
Published in: Journal of Biomedical Optics Volume 16, Issue 8
Show Author Affiliations
Mohammad E. Khosroshahi, Amirkabir Univ. of Technology (Iran, Islamic Republic of)
Mohammad S. Nourbakhsh, Semann Univ. (Iran, Islamic Republic of)

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