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Journal of Biomedical Optics

Differential optical spectropolarimetric imaging system assisted by liquid crystal devices for skin imaging
Author(s): Ofir Aharon; Ibrahim Abdulhalim; Ofer Arnon; Lior Rosenberg; Eldad Silberstein; Victor Dyomin
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Paper Abstract

Skin cancer diagnosis depends not only on histopathological examination but also on visual inspection before and after the excision of suspected lesion. Neoplasm is accompanied with changes in birefringence of collagen, pleomorphicity, and hyperchromatic state of epithelial nuclei. These phenomena can be measured by spectral and polarization changes of light backscattered by the examined tissue. A new differential spectropolarimetric system is proposed using liquid crystal devices, one as a tunable filter and the other as a polarization rotator, both operating at wide spectral ranges from the visible to the near-infrared. Since collagen's fibrils texture orientation depends on its location in the skin and since it is not well organized, our system scans the bipolarization states by continuously rotating the linearly polarized light incident on a skin lesion, and collecting differential contrasts between sequenced images when simultaneously averaging the statistical readout of a video camera. This noninvasive method emphasizes areas on skin where the neoplasm, or tumor, minimizes the statistical polarization change of the scattered light from the lesion. The module can be considered as an assistant tool for epiluminescence microscopy. Images of skin tumors were captured in vivo before the patients having their surgery and compared to histopathological results.

Paper Details

Date Published: 1 August 2011
PDF: 13 pages
J. Biomed. Opt. 16(8) 086008 doi: 10.1117/1.3609003
Published in: Journal of Biomedical Optics Volume 16, Issue 8
Show Author Affiliations
Ofir Aharon, Ben-Gurion Univ. of the Negev (Israel)
Ibrahim Abdulhalim, Ben-Gurion Univ. of the Negev (Israel)
Ofer Arnon, Soroka Univ. Medical Ctr. (Israel)
Lior Rosenberg, Soroka Univ. Medical Ctr. (Israel)
Eldad Silberstein, Soroka Univ. Medical Ctr. (Israel)
Victor Dyomin, Soroka Univ. Medical Ctr. (Israel)

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