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Journal of Biomedical Optics • Open Access

Microfluidic sensing: state of the art fabrication and detection techniques
Author(s): Jing Wu; Min Gu

Paper Abstract

Here we introduce the existing fabrication techniques, detection methods, and related techniques for microfluidic sensing, with an emphasis on the detection techniques. A general survey and comparison of the fabrication techniques were given, including prototyping (hot embossing, inject molding, and soft lithography) and direct fabrication (laser micromachining, photolithography, lithography, and x-ray lithography) techniques. This is followed by an in-depth look at detection techniques: optical, electrochemical, mass spectrometry, as well as nuclear magnetic resonance spectroscopy-based sensing approaches and related techniques. In the end, we highlight several of the most important issues for future work on microfluidic sensing. This article aims at providing a tutorial review with both introductory materials and inspiring information on microfluidic fabrication and sensing for nonspecialists.

Paper Details

Date Published: 1 August 2011
PDF: 13 pages
J. Biomed. Opt. 16(8) 080901 doi: 10.1117/1.3607430
Published in: Journal of Biomedical Optics Volume 16, Issue 8
Show Author Affiliations
Jing Wu, Zhejiang Univ. (China)
Min Gu, Swinburne Univ. of Technology (Australia)

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