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Journal of Biomedical Optics • Open Access

Simultaneous in vivo imaging of melanin and lipofuscin in the retina with photoacoustic ophthalmoscopy and autofluorescence imaging
Author(s): Xiangyang Zhang; Carmen A. Puliafito; Shuliang Jiao; Hao F. Zhang

Paper Abstract

We combined photoacoustic ophthalmoscopy (PAOM) with autofluorescence imaging for simultaneous in vivo imaging of dual molecular contrasts in the retina using a single light source. The dual molecular contrasts come from melanin and lipofuscin in the retinal pigment epithelium (RPE). Melanin and lipofuscin are two types of pigments and are believed to play opposite roles (protective versus exacerbate) in the RPE in the aging process. We have successfully imaged the retina of pigmented and albino rats at different ages. The experimental results showed that multimodal PAOM system can be a potentially powerful tool in the study of age-related degenerative retinal diseases.

Paper Details

Date Published: 1 August 2011
PDF: 4 pages
J. Biomed. Opt. 16(8) 080504 doi: 10.1117/1.3606569
Published in: Journal of Biomedical Optics Volume 16, Issue 8
Show Author Affiliations
Xiangyang Zhang, The Univ. of Southern California (United States)
Carmen A. Puliafito, The Univ. of Southern California (United States)
Shuliang Jiao, The Univ. of Southern California (United States)
Hao F. Zhang, Northwestern Univ. (United States)


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