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Journal of Biomedical Optics • Open Access

Label-free optical activation of astrocyte in vivo
Author(s): Myunghwan Choi; Taeyun Ku; Kyungsun Choi; Chulhee Choi; Jonghee Yoon

Paper Abstract

As the most abundant cell type in the central nervous system, astrocyte has been one of main research topics in neuroscience. Although various tools have been developed, at present, there is no tool that allows noninvasive activation of astrocyte in vivo without genetic or pharmacological perturbation. Here we report a noninvasive label-free optical method for physiological astrocyte activation in vivo using a femtosecond pulsed laser. We showed the laser stimulation robustly induced astrocytic calcium activation in vivo and further verified physiological relevance of the calcium increase by demonstrating astrocyte mediated vasodilation in the brain. This novel optical method will facilitate noninvasive physiological study on astrocyte function.

Paper Details

Date Published: 1 July 2011
PDF: 6 pages
J. Biomed. Opt. 16(7) 075003 doi: 10.1117/1.3600774
Published in: Journal of Biomedical Optics Volume 16, Issue 7
Show Author Affiliations
Myunghwan Choi, KAIST (Korea, Republic of)
Taeyun Ku, KAIST (Korea, Republic of)
Kyungsun Choi, KAIST (Korea, Republic of)
Chulhee Choi, KAIST (Korea, Republic of)
Jonghee Yoon, KAIST (Korea, Republic of)

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