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Journal of Biomedical Optics

Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser: insight into the possible inactivation mechanisms
Author(s): Kong-Thon Tsen; Stephanie Cope; Sara Vaiana; Shaw-Wei David Tsen; Qiang Fu; Stuart M. Lindsay; Zhe Li; Juliann G. Kiang
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Paper Abstract

We report experimental results on the inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by a visible femtosecond laser. Our results suggest that inactivation of virus and bacterium by a visible femtosecond laser involves completely different mechanisms. Inactivation of viruses by a visible femtosecond laser involves the breaking of hydrogen/hydrophobic bonds or the separation of the weak protein links in the protein shell of a viral particle. In contrast, inactivation of bacteria is related to the damage of their DNAs due to irradiation of a visible femtosecond laser. Possible mechanisms for the inactivation of viruses and bacteria are discussed.

Paper Details

Date Published: 1 July 2011
PDF: 9 pages
J. Biomed. Opt. 16(7) 078003 doi: 10.1117/1.3600771
Published in: Journal of Biomedical Optics Volume 16, Issue 7
Show Author Affiliations
Kong-Thon Tsen, Arizona State Univ. (United States)
Stephanie Cope, Arizona State Univ. (United States)
Sara Vaiana, Arizona State Univ. (United States)
Shaw-Wei David Tsen, Washington Univ. School of Medicine in St. Louis (United States)
Qiang Fu, Arizona State Univ. (United States)
Stuart M. Lindsay, Arizona State Univ. (United States)
Zhe Li, Arizona State Univ. (United States)
Juliann G. Kiang, Armed Forces Radiobiology Research Institute (United States)


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