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Journal of Biomedical Optics

Studies on erythrocytes in malaria infected blood sample with Raman optical tweezers
Author(s): Raktim Dasgupta; Ravi S. Verma; Sunita Ahlawat; Abha Uppal; Pradeep K. Gupta
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Paper Abstract

Raman spectroscopy was performed on optically trapped red blood cells (RBCs) from blood samples of healthy volunteers (h-RBCs) and from patients suffering from P. vivax infection (m-RBCs). A significant fraction of m-RBCs produced Raman spectra with altered characteristics relative to h-RBCs. The observed spectral changes suggest a reduced oxygen-affinity or right shifting of the oxygen-dissociation curve for the intracellular hemoglobin in a significant fraction of m-RBCs with respect to its normal functional state.

Paper Details

Date Published: 1 July 2011
PDF: 10 pages
J. Biomed. Opt. 16(7) 077009 doi: 10.1117/1.3600011
Published in: Journal of Biomedical Optics Volume 16, Issue 7
Show Author Affiliations
Raktim Dasgupta, Raja Ramanna Ctr. for Advanced Technology (India)
Ravi S. Verma, Raja Ramanna Ctr. for Advanced Technology (India)
Sunita Ahlawat, Raja Ramanna Ctr. for Advanced Technology (India)
Abha Uppal, Raja Ramanna Ctr. for Advanced Technology (India)
Pradeep K. Gupta, Raja Ramanna Ctr. for Advanced Technology (India)


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