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Journal of Biomedical Optics • Open Access

Detection of rheumatoid arthritis by evaluation of normalized variances of fluorescence time correlation functions
Author(s): Thomas Dziekan; Carmen Weissbach; Jan Voigt; Bernd Ebert; Rainer Macdonald; Malte L. Bahner; Marianne Mahler; Michael Schirner; Michael Berliner; Birgitt Berliner; Jens Osel; Ilka Osel

Paper Abstract

Fluorescence imaging using the dye indocyanine green as a contrast agent was investigated in a prospective clinical study for the detection of rheumatoid arthritis. Normalized variances of correlated time series of fluorescence intensities describing the bolus kinetics of the contrast agent in certain regions of interest were analyzed to differentiate healthy from inflamed finger joints. These values are determined using a robust, parameter-free algorithm. We found that the normalized variance of correlation functions improves the differentiation between healthy joints of volunteers and joints with rheumatoid arthritis of patients by about 10% compared to, e.g., ratios of areas under the curves of raw data.

Paper Details

Date Published: 1 July 2011
PDF: 6 pages
J. Biomed. Opt. 16(7) 076015 doi: 10.1117/1.3599958
Published in: Journal of Biomedical Optics Volume 16, Issue 7
Show Author Affiliations
Thomas Dziekan, Physikalisch-Technische Bundesanstalt (Germany)
Carmen Weissbach, Physikalisch-Technische Bundesanstalt (Germany)
Jan Voigt, Physikalisch-Technische Bundesanstalt (Germany)
Bernd Ebert, Physikalisch-Technische Bundesanstalt (Germany)
Rainer Macdonald, Physikalisch-Technische Bundesanstalt (Germany)
Malte L. Bahner, mivenion GmbH (Germany)
Marianne Mahler, mivenion GmbH (Germany)
Michael Schirner, mivenion GmbH (Germany)
Michael Berliner, HELIOS-Klinikum Berlin-Buch (Germany)
Birgitt Berliner, HELIOS Research Ctr. (Germany)
Jens Osel, HELIOS Klinkum Bad Saarow (Germany)
Ilka Osel, HELIOS klinkum Bad Saarow (Germany)

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