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Journal of Biomedical Optics

Digital optical tomography system for dynamic breast imaging
Author(s): Molly L. Flexman; Michael A. Khalil; Hyun K. Kim; Christopher J. Fong; Andreas H. Hielscher; Rabah Al Abdi; Randall L. Barbour; Elise Desperito; Dawn L. Hershman
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Paper Abstract

Diffuse optical tomography has shown promising results as a tool for breast cancer screening and monitoring response to chemotherapy. Dynamic imaging of the transient response of the breast to an external stimulus, such as pressure or a respiratory maneuver, can provide additional information that can be used to detect tumors. We present a new digital continuous-wave optical tomography system designed to simultaneously image both breasts at fast frame rates and with a large number of sources and detectors. The system uses a master-slave digital signal processor-based detection architecture to achieve a dynamic range of 160 dB and a frame rate of 1.7 Hz with 32 sources, 64 detectors, and 4 wavelengths per breast. Included is a preliminary study of one healthy patient and two breast cancer patients showing the ability to identify an invasive carcinoma based on the hemodynamic response to a breath hold.

Paper Details

Date Published: 1 July 2011
PDF: 17 pages
J. Biomed. Opt. 16(7) 076014 doi: 10.1117/1.3599955
Published in: Journal of Biomedical Optics Volume 16, Issue 7
Show Author Affiliations
Molly L. Flexman, Columbia Univ. (United States)
Michael A. Khalil, Columbia Univ. (United States)
Hyun K. Kim, Columbia Univ. (United States)
Christopher J. Fong, Columbia Univ. (United States)
Andreas H. Hielscher, Columbia Univ. (United States)
Rabah Al Abdi, SUNY Downstate Medical Ctr. (United States)
Randall L. Barbour, SUNY Downstate Medical Ctr. (United States)
Elise Desperito, Columbia Univ. Medical Ctr. (United States)
Dawn L. Hershman, Columbia Univ. Medical Ctr. (United States)

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