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Journal of Biomedical Optics

Low-level laser therapy, at 60 J/cm2 associated with a Biosilicate® increase in bone deposition and indentation biomechanical properties of callus in osteopenic rats
Author(s): Renan Fangel; Paulo Sergio Bossini; Patricia Driusso; Nivaldo A. Parizotto; Ana C. Renno; Daniel A. Ribeiro; Charles Chenwei Wang; Keico Okino Nonaka; Renata L. Toma; Jorge Oishi
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Paper Abstract

We investigate the effects of a novel bioactive material (Biosilicate®) and low-level laser therapy (LLLT), at 60 J/cm2, on bone-fracture consolidation in osteoporotic rats. Forty female Wistar rats are submitted to the ovariectomy, to induce osteopenia. Eight weeks after the ovariectomy, the animals are randomly divided into four groups, with 10 animals each: bone defect control group; bone defect filled with Biosilicate group; bone defect irradiated with laser at 60 J/cm2 group; bone defect filled with Biosilicate and irradiated with LLLT, at 60 J/cm2 group. Laser irradiation is initiated immediately after surgery and performed every 48 h for 14 days. Histopathological analysis points out that bone defects are predominantly filled with the biomaterial in specimens treated with Biosilicate. In the 60-J/cm2 laser plus Biosilicate group, the biomaterial fills all bone defects, which also contained woven bone and granulation tissue. Also, the biomechanical properties are increased in the animals treated with Biosilicate associated to lasertherapy. Our results indicate that laser therapy improves bone repair process in contact with Biosilicate as a result of increasing bone formation as well as indentation biomechanical properties.

Paper Details

Date Published: 1 July 2011
PDF: 6 pages
J. Biomed. Opt. 16(7) 078001 doi: 10.1117/1.3598847
Published in: Journal of Biomedical Optics Volume 16, Issue 7
Show Author Affiliations
Renan Fangel, Univ. Federal de São Carlos (Brazil)
Paulo Sergio Bossini, Univ. Federal de São Carlos (Brazil)
Patricia Driusso, Univ. Federal de São Carlos (Brazil)
Nivaldo A. Parizotto, Univ. Federal de São Carlos (Brazil)
Ana C. Renno, Univ. Federal de São Paulo (Brazil)
Daniel A. Ribeiro, Univ. Federal de São Paulo (Brazil)
Charles Chenwei Wang, Univ. Federal de São Carlos (Brazil)
Keico Okino Nonaka, Univ. Federal de São Carlos (Brazil)
Renata L. Toma, Univ. Federal de São Paulo (Brazil)
Jorge Oishi, Univ. Federal de São Carlos (Brazil)

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