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Journal of Biomedical Optics

Detection of localized inclusions of gold nanoparticles in Intralipid-1% by point-radiance spectroscopy
Author(s): Serge Grabtchak; Tyler J. Palmer; William M. Whelan
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Paper Abstract

Interstitial fiber-optic-based approaches used in both diagnostic and therapeutic applications rely on localized light-tissue interactions. We present an optical technique to identify spectrally and spatially specific exogenous chromophores in highly scattering turbid media. Point radiance spectroscopy is based on directional light collection at a single point with a side-firing fiber that can be rotated up to 360 deg. A side firing fiber accepts light within a well-defined, solid angle, thus potentially providing an improved spatial resolution. Measurements were performed using an 800-μm diameter isotropic spherical diffuser coupled to a halogen light source and a 600 μm, ∼43 deg cleaved fiber (i.e., radiance detector). The background liquid-based scattering phantom was fabricated using 1% Intralipid. Light was collected with 1 deg increments through 360 deg-segment. Gold nanoparticles , placed into a 3.5-mm diameter capillary tube were used as localized scatterers and absorbers introduced into the liquid phantom both on- and off-axis between source and detector. The localized optical inhomogeneity was detectable as an angular-resolved variation in the radiance polar plots. This technique is being investigated as a potential noninvasive optical modality for prostate cancer monitoring.

Paper Details

Date Published: 1 July 2011
PDF: 5 pages
J. Biomed. Opt. 16(7) 077003 doi: 10.1117/1.3597624
Published in: Journal of Biomedical Optics Volume 16, Issue 7
Show Author Affiliations
Serge Grabtchak, Univ. of Prince Edward Island (Canada)
Tyler J. Palmer, Univ. of Prince Edward Island (Canada)
William M. Whelan, Univ. of Prince Edward Island (Canada)

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