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Journal of Biomedical Optics

Photoacoustic tomography of monkey brain using virtual point ultrasonic transducers
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Paper Abstract

A photoacoustic tomography system (PAT) using virtual point ultrasonic transducers was developed and applied to image a monkey brain. The custom-built transducers provide a 10-fold greater field-of-view (FOV) than finite-aperture unfocused transducers as well as an improved signal-to-noise ratio (SNR) and reduced artifacts rather than negative-lens transducers. Their tangential resolution, radial resolution, and (SNR) improvements were quantified using tissue phantoms. Our PAT system can achieve high uniformity in both resolution (<1 mm) and SNR (>8) within a large FOV of 6 cm in diameter, even when the imaging objects are enclosed by a monkey skull. The cerebral cortex of a monkey brain was accurately mapped transcranially, through a skull ranging from 2 to 4 mm in thickness. This study demonstrates that PAT can overcome the optical and ultrasound attenuation of a relatively thick skull and can potentially be applied to human neonatal brain imaging.

Paper Details

Date Published: 1 July 2011
PDF: 6 pages
J. Biomed. Opt. 16(7) 076005 doi: 10.1117/1.3595842
Published in: Journal of Biomedical Optics Volume 16, Issue 7
Show Author Affiliations
Liming Nie, Washington Univ. in St. Louis (United States)
Zijian Guo, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


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