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Journal of Biomedical Optics • Open Access

Design of a handheld optical coherence microscopy endoscope
Author(s): Vrushali R. Korde; Jennifer K. Barton; Erica Liebmann

Paper Abstract

Optical coherence microscopy (OCM) combines coherence gating, high numerical aperture optics, and a fiber-core pinhole to provide high axial and lateral resolution with relatively large depth of imaging. We present a handheld rigid OCM endoscope designed for small animal surgical imaging, with a 6-mm diam tip, 1-mm scan width, and 1-mm imaging depth. X-Y scanning is performed distally with mirrors mounted to micro galvonometer scanners incorporated into the endoscope handle. The endoscope optical design consists of scanning doublets, an afocal Hopkins relay lens system, a 0.4 numerical aperture water immersion objective, and a cover glass. This endoscope can resolve laterally a 1.4-μm line pair feature and has an axial resolution (full width half maximum) of 5.4 μm. Images taken with this endoscope of fresh ex-vivo mouse ovaries show structural features, such as corpus luteum, primary follicles, growing follicles, and fallopian tubes. This rigid handheld OCM endoscope can be useful for a variety of minimally invasive and surgical imaging applications.

Paper Details

Date Published: 1 June 2011
PDF: 9 pages
J. Biomed. Opt. 16(6) 066018 doi: 10.1117/1.3594149
Published in: Journal of Biomedical Optics Volume 16, Issue 6
Show Author Affiliations
Vrushali R. Korde, College of Optical Sciences, The Univ. of Arizona (United States)
Jennifer K. Barton, College of Optical Sciences, The Univ. of Arizona (United States)
Erica Liebmann, The Univ. of Arizona (United States)

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