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Journal of Biomedical Optics

Red-luminescent europium (III) doped silica nanoshells: synthesis, characterization, and their interaction with HeLa cells
Author(s): Jian Yang; Sharraya Aschemeyer; Andrew C. Kummel; William C. Trogler; Sergio Sandoval; Alex Liberman; Jesus Alfaro; David T. Martin; Milan T. Makale
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Paper Abstract

A simple method to fabricate Eu3+ doped silica nanoshells particles with 100 and 200 nm diameters is reported. Amino polystyrene beads were used as templates, and an 8 to 10 nm thick silica gel coating was formed by the sol-gel reaction. After removing the template by calcination, porous dehydrated silica gel nanoshells of uniform size were obtained. The Eu3+ doped silica nanoshells exhibited a red emission at 615 nm on UV excitation. The porous structure of the silica shell wall was characterized by transmission electron microscopy measurements, while particle size and zeta potentials of the particles suspended in aqueous solution were characterized by dynamic light scattering. Two-photon microscopy was used to image the nanoshells after assimilation by HeLa cancer cells.

Paper Details

Date Published: 1 June 2011
PDF: 9 pages
J. Biomed. Opt. 16(6) 066012 doi: 10.1117/1.3593003
Published in: Journal of Biomedical Optics Volume 16, Issue 6
Show Author Affiliations
Jian Yang, Univ. of California, San Diego (United States)
Sharraya Aschemeyer, Univ. of California, San Diego (United States)
Andrew C. Kummel, Univ. of California, San Diego (United States)
William C. Trogler, Univ. of California, San Diego (United States)
Sergio Sandoval, Univ. of California, San Diego (United States)
Alex Liberman, Univ. of California, San Diego (United States)
Jesus Alfaro, Univ. of California, San Diego (United States)
David T. Martin, Univ. of California, San Diego (United States)
Milan T. Makale, Univ. of California, San Diego (United States)


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