Share Email Print
cover

Journal of Biomedical Optics • Open Access

Spectrally resolving and scattering-compensated x-ray luminescence/fluorescence computed tomography
Author(s): Wenxiang Cong; Haiou Shen; Ge Wang

Paper Abstract

The nanophosphors, or other similar materials, emit near-infrared (NIR) light upon x-ray excitation. They were designed as optical probes for in vivo visualization and analysis of molecular and cellular targets, pathways, and responses. Based on the previous work on x-ray fluorescence computed tomography (XFCT) and x-ray luminescence computed tomography (XLCT), here we propose a spectrally-resolving and scattering-compensated x-ray luminescence/fluorescence computed tomography (SXLCT or SXFCT) approach to quantify a spatial distribution of nanophosphors (other similar materials or chemical elements) within a biological object. In this paper, the x-ray scattering is taken into account in the reconstruction algorithm. The NIR scattering is described in the diffusion approximation model. Then, x-ray excitations are applied with different spectra, and NIR signals are measured in a spectrally resolving fashion. Finally, a linear relationship is established between the nanophosphor distribution and measured NIR data using the finite element method and inverted using the compressive sensing technique. The numerical simulation results demonstrate the feasibility and merits of the proposed approach.

Paper Details

Date Published: 1 June 2011
PDF: 8 pages
J. Biomed. Opt. 16(6) 066014 doi: 10.1117/1.3592499
Published in: Journal of Biomedical Optics Volume 16, Issue 6
Show Author Affiliations
Wenxiang Cong, Virginia Polytechnic Institute and State Univ. (United States)
Haiou Shen, Virginia Polytechnic Institute and State Univ. (United States)
Ge Wang, Virginia Polytechnic Institute and State Univ. (United States)


© SPIE. Terms of Use
Back to Top