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Journal of Biomedical Optics • Open Access

Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy
Author(s): Vladimir M. Turzhitsky; Andrew J. Radosevich; Jeremy D. Rogers; Nikhil N. Mutyal; Vadim Backman

Paper Abstract

Low-coherence enhanced backscattering (LEBS) is a depth selective technique that allows noninvasive characterization of turbid media such as biological tissue. LEBS provides a spectral measurement of the tissue reflectance distribution as a function of distance between incident and reflected ray pairs through the use of partial spatial coherence broadband illumination. We present LEBS as a new depth-selective technique to measure optical properties of tissue in situ. Because LEBS enables measurements of reflectance due to initial scattering events, LEBS is sensitive to the shape of the phase function in addition to the reduced scattering coefficient (μs*). We introduce a simulation of LEBS that implements a two parameter phase function based on the Whittle-Matérn refractive index correlation function model. We show that the LEBS enhancement factor (E) primarily depends on μs*, the normalized spectral dependence of E (Sn) depends on one of the two parameters of the phase function that also defines the functional type of the refractive index correlation function (m), and the LEBS peak width depends on both the anisotropy factor (g) and m. Three inverse models for calculating these optical properties are described and the calculations are validated with an experimental measurement from a tissue phantom.

Paper Details

Date Published: 1 June 2011
PDF: 15 pages
J. Biomed. Opt. 16(6) 067007 doi: 10.1117/1.3589349
Published in: Journal of Biomedical Optics Volume 16, Issue 6
Show Author Affiliations
Vladimir M. Turzhitsky, Northwestern Univ. (United States)
Andrew J. Radosevich, Northwestern Univ. (United States)
Jeremy D. Rogers, Northwestern Univ. (United States)
Nikhil N. Mutyal, Northwestern Univ. (United States)
Vadim Backman, Northwestern Univ. (United States)

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