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Journal of Biomedical Optics

Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging
Author(s): Jiechen Yin; Jiawen Li; Zhongping Chen; Xiang Li; Kirk K. Shung; Qifa Zhou; Joseph Jing; David Sho Mukai; Sari B. Mahon; Matthew Brenner; Ahmad Edris; Ahmad Khiet C. Hoang; Jagat Narula
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Paper Abstract

We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as well. The OCT and ultrasound probes were integrated as a single probe to obtain OCT and ultrasound images simultaneously. The integrated probe has an outer diameter of 0.69 mm which, to our knowledge, is the smallest integrated OCT-US probe reported. Fast data acquisition and processing was implemented for real-time imaging. In vitro OCT and US images of human coronary artery with pathology, as well as in vivo images of normal rabbit abdominal aorta, were obtained using the integrated OCT-US probe to demonstrate its capability.

Paper Details

Date Published: 1 June 2011
PDF: 4 pages
J. Biomed. Opt. 16(6) 060505 doi: 10.1117/1.3589097
Published in: Journal of Biomedical Optics Volume 16, Issue 6
Show Author Affiliations
Jiechen Yin, Univ. of California, Irvine (United States)
Jiawen Li, Univ. of California, Irvine (United States)
Zhongping Chen, Univ. of California, Irvine (United States)
Xiang Li, The Univ. of Southern California (United States)
Kirk K. Shung, The Univ. of Southern California (United States)
Qifa Zhou, The Univ. of Southern California (United States)
Joseph Jing, Beckman Laser Institute and Medical Clinic (United States)
David Sho Mukai, Beckman Laser Institute and Medical Clinic (United States)
Sari B. Mahon, Beckman Laser Institute and Medical Clinic (United States)
Matthew Brenner, Univ. of California, Irvine (United States)
Ahmad Edris, Univ. of California, Irvine (United States)
Ahmad Khiet C. Hoang, Univ. of California, Irvine (United States)
Jagat Narula, Univ. of California, Irvine (United States)


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