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Journal of Biomedical Optics

In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury
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Paper Abstract

For the first time, we have implemented photoacoustic tomography (PAT) to image the water content of an edema in vivo. We produced and imaged a cold-induced cerebral edema transcranially, then obtained blood vessel and water accumulation images at 610 and 975 nm, respectively. We tracked the changes at 12, 24, and 36 h after the cold injury. The blood volume decreased after the cold injury, and the maximum area of edema was observed 24 h after the cold injury. We validated PAT of the water content of the edema through magnetic Resonance Imaging and the water spectrum from the spectrophotometric measurement.

Paper Details

Date Published: 1 June 2011
PDF: 5 pages
J. Biomed. Opt. 16(6) 066020 doi: 10.1117/1.3584847
Published in: Journal of Biomedical Optics Volume 16, Issue 6
Show Author Affiliations
Zhun Xu, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)
Quing Zhu, Univ. of Connecticut (United States)

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