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Journal of Biomedical Optics • Open Access

Characterization of individual ultrasound microbubble dynamics with a light-scattering system
Author(s): Mark J. Hsu; Sadik C. Esener; Mohammad Eghtedari; David J. Hall; Robert F. Mattrey; Andrew P. Goodwin

Paper Abstract

Ultrasound microbubbles are contrast agents used for diagnostic ultrasound imaging and as carriers for noninvasive payload delivery. Understanding the acoustic properties of individual microbubble formulations is important for optimizing the ultrasound imaging parameters for improved image contrast and efficient payload delivery. We report here a practical and simple optical tool for direct real-time characterization of ultrasound contrast microbubble dynamics based on light scattering. Fourier transforms of raw linear and nonlinear acoustic oscillations, and microbubble cavitations are directly recorded. Further, the power of this tool is demonstrated by comparing clinically relevant microbubble cycle-to-cycle dynamics and their corresponding Fourier transforms.

Paper Details

Date Published: 1 June 2011
PDF: 5 pages
J. Biomed. Opt. 16(6) 067002 doi: 10.1117/1.3583575
Published in: Journal of Biomedical Optics Volume 16, Issue 6
Show Author Affiliations
Mark J. Hsu, Univ. of California, San Diego (United States)
Sadik C. Esener, Univ. of California, San Diego (United States)
Mohammad Eghtedari, Univ. of California, San Diego (United States)
David J. Hall, Univ. of California, San Diego (United States)
Robert F. Mattrey, Univ. of California, San Diego (United States)
Andrew P. Goodwin, Univ. of California, San Diego (United States)


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