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Journal of Biomedical Optics • Open Access

Measuring changes in chemistry, composition, and molecular structure within hair fibers by infrared and Raman spectroscopic imaging
Author(s): Guojin Zhang; Laurence Senak; David J. Moore

Paper Abstract

Spatially resolved infrared (IR) and Raman images are acquired from human hair cross sections or intact hair fibers. The full informational content of these spectra are spatially correlated to hair chemistry, anatomy, and structural organization through univariate and multivariate data analysis. Specific IR and Raman images from untreated human hair describing the spatial dependence of lipid and protein distribution, protein secondary structure, lipid chain conformational order, and distribution of disulfide cross-links in hair protein are presented in this study. Factor analysis of the image plane acquired with IR microscopy in hair sections, permits delineation of specific micro-regions within the hair. These data indicate that both IR and Raman imaging of molecular structural changes in a specific region of hair will prove to be valuable tools in the understanding of hair structure, physiology, and the effect of various stresses upon its integrity.

Paper Details

Date Published: 1 May 2011
PDF: 8 pages
J. Biomed. Opt. 16(5) 056009 doi: 10.1117/1.3580286
Published in: Journal of Biomedical Optics Volume 16, Issue 5
Show Author Affiliations
Guojin Zhang, International Specialty Products, Inc. (United States)
Laurence Senak, International Specialty Products, Inc. (United States)
David J. Moore, International Specialty Products, Inc. (United States)


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