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Journal of Biomedical Optics

Survey on indirect optical manipulation of cells, nucleic acids, and motor proteins
Author(s): Ashis G. Banerjee; Sagar Chowdhury; Satyandra K. Gupta; Wolfgang Losert
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Paper Abstract

Optical tweezers have emerged as a promising technique for manipulating biological objects. Instead of direct laser exposure, more often than not, optically-trapped beads are attached to the ends or boundaries of the objects for translation, rotation, and stretching. This is referred to as indirect optical manipulation. In this paper, we utilize the concept of robotic gripping to explain the different experimental setups which are commonly used for indirect manipulation of cells, nucleic acids, and motor proteins. We also give an overview of the kind of biological insights provided by this technique. We conclude by highlighting the trends across the experimental studies, and discuss challenges and promising directions in this domain of active current research.

Paper Details

Date Published: 1 May 2011
PDF: 12 pages
J. Biomed. Opt. 16(5) 051302 doi: 10.1117/1.3579200
Published in: Journal of Biomedical Optics Volume 16, Issue 5
Show Author Affiliations
Ashis G. Banerjee, Massachusetts Institute of Technology (United States)
Sagar Chowdhury, Univ. of Maryland, College Park (United States)
Satyandra K. Gupta, Univ. of Maryland, College Park (United States)
Wolfgang Losert, Univ. of Maryland, College Park (United States)

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