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Journal of Biomedical Optics

Silver nanostructure sensing platform for maximum-contrast fluorescence cell imaging
Author(s): Kyung-Min Lee; Arup Neogi; Purnima B. Neogi; Minjung Kim; Bongsoo Kim; Rafal Luchowski; Zygmunt K. Gryczynski; Nils Calander; Tae-Youl Choi
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Paper Abstract

We present herein a silver nanostructure-assisted sensing platform which consists of a combined structure of Ag nanowire (NW) and nanodot (ND) array. Highly enhanced fluorescence from fluorophore is attributed to a strongly coupled optical near-field interaction between proximately located Ag NW and NDs. We obtained enhanced fluorescence intensity with up to 140 folds, as contrasted from background intensity, reaching a theoretical maximum value. On the other hand, fluorescence lifetime was greatly reduced to 0.27 ns (from 2.17 ns for the same fluorophores without nanostructure). This novel platform can be a promising utility for optical imaging and labeling of biological systems with a great sensitivity.

Paper Details

Date Published: 1 May 2011
PDF: 6 pages
J. Biomed. Opt. 16(5) 056008 doi: 10.1117/1.3579157
Published in: Journal of Biomedical Optics Volume 16, Issue 5
Show Author Affiliations
Kyung-Min Lee, Univ. of North Texas (United States)
Arup Neogi, Univ. of North Texas (United States)
Purnima B. Neogi, Univ. of North Texas (United States)
Minjung Kim, KAIST (Korea, Republic of)
Bongsoo Kim, KAIST (Korea, Republic of)
Rafal Luchowski, Univ. of North Texas Health Science Ctr. at Fort Worth (United States)
Zygmunt K. Gryczynski, Univ. of North Texas Health Science Ctr. at Fort Worth (United States)
Nils Calander, Macquarie Univ. (Australia)
Tae-Youl Choi, Univ. of North Texas (United States)

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