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Journal of Biomedical Optics

Terahertz sensing in corneal tissues
Author(s): David B. Bennett; Zachary D. Taylor; Priyamvada Tewari; Rahul S. Singh; Martin O. Culjat; Warren S. Grundfest; Daniel J. Sassoon; R. Duncan Johnson; Jean-Pierre Hubschman; Elliott Brown
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Paper Abstract

This work introduces the potential application of terahertz (THz) sensing to the field of ophthalmology, where it is uniquely suited due to its nonionizing photon energy and high sensitivity to water content. Reflective THz imaging and spectrometry data are reported on ex-vivo porcine corneas prepared with uniform water concentrations using polyethylene glycol (PEG) solutions. At 79% water concentration by mass, the measured reflectivity of the cornea was 20.4%, 14.7%, 11.7%, 9.6%, and 7.4% at 0.2, 0.4, 0.6, 0.8, and 1 THz, respectively. Comparison of nine corneas hydrated from 79.1% to 91.5% concentration by mass demonstrated an approximately linear relationship between THz reflectivity and water concentration, with a monotonically decreasing slope as the frequency increases. The THz-corneal tissue interaction is simulated with a Bruggeman model with excellent agreement. THz applications to corneal dystrophy, graft rejection, and refractive surgery are examined from the context of these measurements.

Paper Details

Date Published: 1 May 2011
PDF: 9 pages
J. Biomed. Opt. 16(5) 057003 doi: 10.1117/1.3575168
Published in: Journal of Biomedical Optics Volume 16, Issue 5
Show Author Affiliations
David B. Bennett, Univ. of California, Los Angeles (United States)
Zachary D. Taylor, Univ. of California, Los Angeles (United States)
Priyamvada Tewari, Univ. of California, Los Angeles (United States)
Rahul S. Singh, Univ. of California, Los Angeles (United States)
Martin O. Culjat, Univ. of California, Los Angeles (United States)
Warren S. Grundfest, Univ. of California, Los Angeles (United States)
Daniel J. Sassoon, Jules Stein Eye Institute (United States)
R. Duncan Johnson, Jules Stein Eye Institute (United States)
Jean-Pierre Hubschman, Jules Stein Eye Institute (United States)
Elliott Brown, Wright State Univ. (United States)


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