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Journal of Biomedical Optics • Open Access

Confocal imaging reveals three-dimensional fine structure difference between ventral and dorsal nerve roots
Author(s): Yuxiang Wu; Xiaohua Lv; Shaoqun Zeng; Tao Sui; Xiaojian Cao; Peng Sun

Paper Abstract

Peripheral nerve injury repair is one of the most challenging problems in neurosurgery, partially due to lack of knowledge of three-dimensional (3-D) fine structure and organization of peripheral nerves. In this paper, we explored the structures of nerve fibers in ventral and dorsal nerves with a laser scanning confocal microscopy. Thick tissue staining results suggested that nerve fibers have a different 3-D structure in ventral and dorsal nerves, and reconstruction from serial sectioning images showed that in ventral nerves the nerve fibers travel in a winding form, while in dorsal nerves, the nerve fibers form in a parallel cable pattern. These structural differences could help surgeons to differentiate ventral and dorsal nerves in peripheral nerve injury repair, and also facilitate scientists to get a deeper understanding about nerve fiber organization.

Paper Details

Date Published: 1 May 2011
PDF: 4 pages
J. Biomed. Opt. 16(5) 050502 doi: 10.1117/1.3575167
Published in: Journal of Biomedical Optics Volume 16, Issue 5
Show Author Affiliations
Yuxiang Wu, Huazhong Univ. of Science and Technology (China)
Xiaohua Lv, Huazhong Univ. of Science and Technology (China)
Shaoqun Zeng, Huazhong Univ. of Science and Technology (China)
Tao Sui, Nanjing Medical Univ. (China)
Xiaojian Cao, Nanjing Medical Univ. (China)
Peng Sun, Nanjing Medical Univ. (China)

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