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Optical Engineering

Optical tomograph optimized for tumor detection inside highly absorbent organs
Author(s): Jerome Boutet; Anne Koenig; Lionel Hervé; Michel Berger; Jean-Marc Dinten; Véronique Josserand; Jean-Luc Coll
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Paper Abstract

This paper presents a tomograph for small animal fluorescence imaging. The compact and cost-effective system described in this article was designed to address the problem of tumor detection inside highly absorbent heterogeneous organs, such as lungs. To validate the tomograph's ability to detect cancerous nodules inside lungs, in vivo tumor growth was studied on seven cancerous mice bearing murine mammary tumors marked with Alexa Fluor 700. They were successively imaged 10, 12, and 14 days after the primary tumor implantation. The fluorescence maps were compared over this time period. As expected, the reconstructed fluorescence increases with the tumor growth stage.

Paper Details

Date Published: 1 May 2011
PDF: 7 pages
Opt. Eng. 50(5) 053203 doi: 10.1117/1.3574768
Published in: Optical Engineering Volume 50, Issue 5
Show Author Affiliations
Jerome Boutet, Commissariat à l'Énergie Atomique (France)
Anne Koenig, Commissariat à l'Énergie Atomique (France)
Lionel Hervé, Commissariat à l'Énergie Atomique (France)
Michel Berger, Commissariat à l'Énergie Atomique (France)
Jean-Marc Dinten, Commissariat à l'Énergie Atomique (France)
Véronique Josserand, Institut Albert Bonniot (France)
Jean-Luc Coll, Institut Albert Bonniot (France)

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