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Journal of Biomedical Optics

Real-time snapshot hyperspectral imaging endoscope
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Paper Abstract

Hyperspectral imaging has tremendous potential to detect important molecular biomarkers of early cancer based on their unique spectral signatures. Several drawbacks have limited its use for in vivo screening applications: most notably the poor temporal and spatial resolution, high expense, and low optical throughput of existing hyperspectral imagers. We present the development of a new real-time hyperspectral endoscope (called the image mapping spectroscopy endoscope) based on an image mapping technique capable of addressing these challenges. The parallel high throughput nature of this technique enables the device to operate at frame rates of 5.2 frames per second while collecting a (x, y, λ) datacube of 350 × 350 × 48. We have successfully imaged tissue in vivo, resolving a vasculature pattern of the lower lip while simultaneously detecting oxy-hemoglobin.

Paper Details

Date Published: 1 May 2011
PDF: 13 pages
J. Biomed. Opt. 16(5) 056005 doi: 10.1117/1.3574756
Published in: Journal of Biomedical Optics Volume 16, Issue 5
Show Author Affiliations
Robert T. Kester, Rice Univ. (United States)
Noah Bedard, Rice Univ. (United States)
Liang S. Gao, Rice Univ. (United States)
Tomasz S. Tkaczyk, Rice Univ. (United States)


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