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Journal of Biomedical Optics

Semiautomated analysis of optical coherence tomography crystalline lens images under simulated accommodation
Author(s): Eon Kim; Klaus Ehrmann; Jean-Marie Parel; Stephen Uhlhorn; David Borja; Esdras Arrieta-Quintero
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Paper Abstract

Presbyopia is an age related, gradual loss of accommodation, mainly due to changes in the crystalline lens. As part of research efforts to understand and cure this condition, ex vivo, cross-sectional optical coherence tomography images of crystalline lenses were obtained by using the Ex-Vivo Accommodation Simulator (EVAS II) instrument and analyzed to extract their physical and optical properties. Various filters and edge detection methods were applied to isolate the edge contour. An ellipse is fitted to the lens outline to obtain central reference point for transforming the pixel data into the analysis coordinate system. This allows for the fitting of a high order equation to obtain a mathematical description of the edge contour, which obeys constraints of continuity as well as zero to infinite surface slopes from apex to equator. Geometrical parameters of the lens were determined for the lens images captured at different accommodative states. Various curve fitting functions were developed to mathematically describe the anterior and posterior surfaces of the lens. Their differences were evaluated and their suitability for extracting optical performance of the lens was assessed. The robustness of these algorithms was tested by analyzing the same images repeated times.

Paper Details

Date Published: 1 May 2011
PDF: 12 pages
J. Biomed. Opt. 16(5) 056003 doi: 10.1117/1.3574613
Published in: Journal of Biomedical Optics Volume 16, Issue 5
Show Author Affiliations
Eon Kim, Brien Holden Vision Institute (Australia)
Klaus Ehrmann, Brien Holden Vision Institute (Australia)
Jean-Marie Parel, Bascom Palmer Eye Institute (United States)
Stephen Uhlhorn, Bascom Palmer Eye Institute (United States)
David Borja, Bascom Palmer Eye Institute (United States)
Esdras Arrieta-Quintero, Bascom Palmer Eye Institute (United States)

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